1022 Engineering a tri-specific antibody targeting PD-1, IL-2, and butyrate to reprogram cold tumors
PD-1 checkpoint blockadeimmunotherapyCold solid tumorsbutyratemicrosatellite stable colorectal cancers
…t the efficacy of therapies reliant on T-cell activity, such as PD-1 checkpoint blockade.1 Immune stimulatory agents interleukin-2 (IL-2) and the microb…