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…equently used herbs were Zataria multiflora, Echium amoenum and Matricaria chamomilla, most commonly for anxiety/neurasthenia (81.6%), gastric pain (…

…Background Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) delay gastric emptying and may increase aspiration risk, but t…

…apeutic modalities include medical (antihypertensive, steroids, cyclophosphamide, etc) as well as surgical interventions.…

…24%) were positive for Scl-70, 821 (24%) for ACA, 416 (12%) for RNA POLII, and 1,331 (40%) were only ANA positive. 87% were females, mean…

…ore. Finally, in vitro treatment of human skin fibroblasts with STM2457 significantly ameliorated the TGF-beta-induced increase in proi…

…, notably in dcSSc patients with high fibrotic score. CycIF and Tyramide stainings showed increased vascular apoptosis together with alt…

…, essential for vascular integrity, are negatively regulated by TGFB. Clinically, complications often begin in one organ and later i…

…ered energy metabolism during fibrotic activation. Importantly, nintedanib pretreatment reduced both fibrotic gene expression (figure 2C) …

… by recombinant S100A4, and significantly attenuated in SScF by AX-202.Material and Methods Gene set enrichment analysis interrogated …

…, smoking status, and age. Sea salt exposure was protective for anti-centromere (ACA) (OR=0.10, CI=0.01-0.71, p=0.03) and organic matter was as…

…apillary density; and mitochondrial dysregulation. Importantly, interferon signals (e.g. CXCL10) are associated with microvasculopathy, mi…

…uently treated with corticosteroids (79.3% vs. 67.9%, p=0.003), cyclophosphamide (43.4% vs. 26%, p<0.001), and azathioprine (38.5% vs. 22.3%, p=…