…Background Chimeric antigen receptor macrophages (CAR-M) represent a promising immunotherapy candidate for solid tumors…
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Showing 1,501–1,560 of 9,496, ordered by supporting articles. Choose a drug to see its evidence.
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10,506 articles · page 567 of 876…n of CD73 on U266B1 cells at high levels (>90%). Treatment with CD73 mAb had a significant cytotoxic effect against U266B1 cells in …
…eptor (CAR) T cell manufacturing is associated with high costs. LipidBrick® Cell Ready is a novel lipid-based nanoparticle solution that can be easily…
… UniCAR-T cells redirected with increasing concentrations of an anti-CD33 TM against acute myeloid leukemia (HL-60) cells.Results Tracking t…
…hese two genes in CART cells that were costimulated with either 4-1BB or CD28. Ultimately, our study indicates that UACA and NEFM ove…
… future preclinical in vivo studies and clinical development of CART87.…
…ful applications of this approach across diverse CGTs—including CAR-T, CAR-NK, TCR-T cells, and extracellular vesicles—in both autolo…
…B sensitivity in vivo. These results suggest that TAM-targeting CAR-Mo offers a first-in-class platform to improve the effectiveness o…
…d (4) overcoming immunosuppression by armoring CAR T cells with dnTGFβRII. Bispecific secretion is restricted to NFAT-activated CAR T cel…
…in part by changes in E3 expression. Notably, overexpression of RNF166 in T-cells significantly enhances persistence, highlighting a p…
…nclusions Our results demonstrate that non-viral integration of IL-15-armored CAR into the CISH locus via a simplified one-step genome editing pr…
…1-00842-6Yang Z, et al. Nanoscale, antigen encounter-dependent, IL-12 delivery by CAR T cells plus PD-L1 blockade for cancer treatmen…