…nsidered treatment-related and a DLT) that led to withdrawal of ASP1012. A second DLT occurred (dose: 3×109) of prolonged grade 3 eleva…
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10,506 articles · page 173 of 876… the safety, efficacy, pharmacokinetics and pharmacodynamics of EVOLVE104 in subjects with locally advanced or metastatic solid tumors, r…
…t for patients resistant to immune checkpoint inhibitors (ICI). Ateganosine (THIO; 6-thio-2’-deoxyguanosine) is recognized by telomerase an…
…inhibition dependent changes in anti-tumor immunity.Conclusions BAY2965501 demonstrates pharmacodynamic PoM in monotherapy and combination…
…rming successful engraftment and tumor infiltration.Conclusions AGX-148 offers a novel, biomarker selection strategy enriching for tumo…
…o responses to ubamatamab did not correlate with sensitivity to pembrolizumab or chemotherapy, suggesting this therapy may benefit a distinct…
…7), as of 28Feb2025, 29 patients with CPI-R/R melanoma received pembrolizumab (400 mg IV Q6W) plus mRNA-4359 (400 µg [n=14] or 1000 µg [n=15]…
…orm. Under US-IT each tumor mass was treated on day 0 (D0) with liposomal doxorubicin, oxaliplatin, and combretastatin A4 Phosphate (CA4P) (0.125 mg,…
…in response to both single-agent and combination treatment with carboplatin and docetaxel. Multiparameter flow cytometry demonstrated a het…
…ther enhance anti-AML efficacy of CD33.CAR NK cells and whether NKTR-255 (polymer conjugated IL15)3 further augments these effects.Metho…
…ture clinical studies are warranted to validate the efficacy of IPT001 as a monotherapy and in combination with standard-of-care treat…
… in vivo with the orally bioavailable, small molecule inhibitor PLN-101095, which was administered in the mouse chow.Results and Conclusio…