…nd with low uM affinity to the Fc receptor FcGRIIIa, similar to Rituximab.Conclusions We demonstrate the feasibility of using an Fc-fusio…
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10,506 articles · page 366 of 876…munogenic, immune checkpoint blockade-resistant melanoma model, PROTAC HPK1 degraders elicited superior TGI (79%) vs an anti-PD-1 anti…
…a murine tumor-associated antigen (TAA), which we targeted with ChAdOx1/MVA-P1A vaccines. Furthermore, we developed a pipeline to ident…
…tor cabozantinib and the anti-PD-L1 immune checkpoint inhibitor nivolumab in patients with unresectable HCC ( NCT03299946). Major patholo…
…ation of tumor-associated macrophages (TAMs) via suppression of IFN-γ.5–8 Here, we investigate whether immune suppression mediated by…
…m multiple independent cohorts, including patients treated with ICIs, collected via whole-exome sequencing and targeted sequencing. …
…engineered CAR-T cells to express a membrane-bound DR5 agonist (aDR5) lacking intracellular signaling capabilities to induce apoptos…
…d genomic stability and lack of oncogenic potential.Conclusions UCCT-BCMA-1 has successfully received IND-clearance to initiate Phase-I cli…
…reen S, Broggi, MAS, Hatke AL, et al. Preclinical evaluation of AZD6422, an armored chimeric antigen receptor T cell targeting CLDN18.2…
… chloroalkane (CA) motif, the adaptors covalently attach to the HaloCAR, arming it to attack tumor cells.Methods We generated antibody-…
…the synergistic effects of a clinically approved PGC1α agonist, bezafibrate, in combination with CAR T cell therapy. This dual treatment dr…
…al persistence.Methods To evaluate suitable target antigens for AB-3028, we first conducted a comprehensive in silico analyses with bul…