Entity family
Named medicines, compounds, vaccines, and pharmacological agents. Examples include metformin, semaglutide, antibiotics.
Showing 781–840 of 9,496, ordered by supporting articles. Choose a drug to see its evidence.
…we present initial data from the first-in-human trial employing CRISPR-Cas9 to knockout PD-1 in TILs from patients with metastatic melanoma…
… group).Results Before RT, KAPP cells showed high expression of STING transcriptionally. After RT, higher apoptosis was observed in b…
…hibition of Notch signaling with a γ-secretase inhibitor (GSI), AL101, would overcome radiation-induced immunosuppression and synergi…
…estigational. These include immune checkpoint inhibitors (PD-1, PD-L1, OX40), bispecific T engagers (CD3xCD20 or CD3xEGFR), and tumor…
…endogenous ATF6 was achieved using the small molecule activator AA147. ATF6 pathway activation was validated by qPCR and immunoblotti…
…g autopsy, and breast biopsy samples followed by detection with HCR™ Pro. Performance was benchmarked against traditional HRP-based dete…
… our prior identification of the natural flavonoids chrysin and galangin as DPP4 inhibitors, we propose their investigation as part of a…
…Background Immune checkpoint inhibitors (ICIs) continue to have an increasing role in oncology, offerin…
…ared to wild type. Notably, co-treatment with the ERK inhibitor LY3214996 effectively reversed SAHA resistance induced by PLCG1 mutations…
…e of therapeutics entering clinical development. In particular, cytokines have received significant attention due to their potential to c…
… Furthermore, the combination of HEK293-derived IL-2, IL-7, and IL-15 resulted in robust expansion of T cells with a favorable phenot…
…ls, which decreased upon pre-treatment (receptor blockade) with cetuximab. Secondly, immunofluorescence staining for γH2Ax foci noted tha…