…nflammatory TAMs can support CAR T-cell function. We identified Resiquimod, a Toll-like receptor (TLR) 7/8 agonist, as a potent immunomodu…
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10,506 articles · page 303 of 876…γ receptors. This combination of NK cell adoptive transfer with pegenzileukin treatment resulted in remarkable enhancement of NK cell persist…
…ssion and sustained antitumor responses (figure 2). Remarkably, Neo4 conjugation not only enhanced the efficacy of ACT but also redu…
…combination with the immune checkpoint inhibitors nivolumab and ipilimumab. We analyzed PBMCs from a subset of patients who demonstrated a…
…nor material representing the intended clinical product.Results TK-6302 contained 39-48% TCR negative T cells (knock out) and 24-42% PR…
…reatment of solid cancers, including PDAC and CRC, we developed AZD0240, a CRISPR-engineered autologous TCR-T cell product targeting KR…
…ly results, we will further define the therapeutic potential of CAR-TIL and will evaluate their therapeutic value for clinical translat…
…eried to evaluate post-marketing adverse events associated with lifileucel. All reports submitted from initial market availability through…
…ts. Here we describe a novel two-component therapeutic regimen, DISP-10, which consists of a tumor specific and intravenously administe…
…experienced severe reactions. The five most reported drugs were nivolumab (92,753; 44.4%), pembrolizumab (62,096; 29.7%), atezolizumab (3…
…d with anti-tumor effects.9 10 Methods In this study, we employ OSU-ERβ-12, a potent, carborane-based molecule that can selectively target…