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Named medicines, compounds, vaccines, and pharmacological agents. Examples include metformin, semaglutide, antibiotics.

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850 HM16390, a long-acting IL-2 analog with enhanced IL-2Rβ binding and optimal IL-2Rα binding, selectively expands tumor-specific T cells, resulting in potent anti-tumor immunity in murine tumor models

jitc · abstract · 2025-11-04 · 2 matching annotations

78.4%

HM16390 paclitaxel non-alpha variant MC38 tumors C57BL/6 mice

…in only marginal tumor control (<40% TGI) without achieving CR. HM16390 elicited an improved, yet still insufficient, anti-tumor activi…