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…Daridorexant is a dual orexin receptor antagonist approved for the treatment…

… to AEs (both in placebo). One participant reported somnolence (daridorexant 50 mg).Daridorexant 50 mg improved sleep among patients with co…

…exant 25 mg reduced WASO by -6.2 min, -7.2 min and -7.6 min and daridorexant 50 mg reduced WASO by -8.7 min, -9.6 min, -11.3 min in Q2, Q3 a…

…n LSM (95% CI) of 0.14 (0.02, 0.27) and 0.47 (0.34, 0.59) s for daridorexant 25 and 50 mg, respectively. The VVLT showed minimal differences…

…es in WASO in Q2-4 of the night were numerically larger in both daridorexant dose groups versus placebo.. At M1 and M3, both daridorexant 50…

…ion. This is the first evaluation of the efficacy and safety of daridorexant (a novel insomnia treatment), specifically in an age group repr…

…Introduction Daridorexant is a dual orexin receptor antagonist approved for the treatment…

…ociated with tolerance, dependence, and cognitive side effects. Daridorexant, a dual orexin receptor antagonist (DORA), was recently license…

…lerability, pharmacokinetics, palatability and acceptability of daridorexant.Ethics and dissemination This study has been approved by the re…

…hase III clinical trials of the dual orexin receptor antagonist daridorexant. The replication study PAUSe 2.0 extended this study to assess …