Entity family
Named medicines, compounds, vaccines, and pharmacological agents. Examples include metformin, semaglutide, antibiotics.
This drug is selected. Its supporting articles are shown below.
…e inhibitors, epigenetic modifiers and apoptosis promoters (eg, BCL-2 inhibitors). Despite their growing use, these therapies are poorly studied…
…ased immunotherapies—chimeric antigen receptor T (CAR-T) cells, checkpoint inhibitors, and neoantigen vaccines—share a fundamental vulnerability: the…
…ncer. TAA vaccines failed as monotherapy but the development of checkpoint inhibitors and other reagents that can modify immunosuppressive tumor micr…
…Checkpoint inhibitors best perform in neoadjuvant settings for a number of solid mali…
…and IL-12 NPs (p<0.001). In vivo, both groups delivering 4-1BBL/IL-12 NPs demonstrated significantly improved survival compared to th…
… immune-related adverse events (IRAEs) in patients treated with checkpoint inhibitors.Methods We analyzed peripheral blood mononuclear cell (PBMC) sa…
…Background Checkpoint inhibitors have emerged as a standard of care therapy for non-small cell l…
…ssociated with favorable outcomes only in patients treated with anti-CTLA4 (p<0.05). ScRNA analysis revealed elevated expression of NLRC5 …
…tes such as the liver, which is significantly more resistant to checkpoint inhibitors (ICIs).Methods Using syngeneic melanoma cells, we optimized int…
… responses to intravesical CS/IL-12.Conclusions Intravesical CS/caIL-12 treatments have been generally well-tolerated. Five dose levels…
…n several cancer models, and potentiated PD-1 blockade therapy. TAT003 treatment induced the expansion of cancer-cell specific effecto…
…ents the most lethal gynecological cancer with poor response to checkpoint inhibitors. Human endogenous retroviruses (HERVs) are aberrantly expressed…