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…jectives Following the successful AURORA-1 and AURORA-2 trials, voclosporin was incorporated into the KDIGO 2024 clinical guidelines for th…

…omitant immunosuppressive biologics in LN patients treated with voclosporin. This is notable given the unique and possibly synergistic effe…

…ods A retrospective analysis included SLE patients treated with belimumab (n=25), obinutuzumab (n=8), and voclosporin (n=3) for >=6 month…

…ty index was 6.4 (SD 5.4) and the chronicity index 2.6 (SD 2.5).Voclosporin was used as initial therapy for active LN in 7 cases, as rescue…

…addition of two immunosuppressive therapies, anchored on either belimumab or voclosporin.3 4 Glucocorticoids should be administered initi…

…ximab, and plasmapheresis, followed by maintenance therapy with mycophenolate mofetil and voclosporin, can result in significant renal and pulmonary …

…H, Houssiau F, et al. Two-year, randomized, controlled trial of belimumab in lupus nephritis. N Engl J Med. 2020;383(12):1117–28. doi: 10…

…, ANI was administered concomitantly with antimalarials (n=16), mycophenolate mofetil (n=11), tacrolimus (n=4), azathioprine (n=2), methotrexate (n=1…

…b in 25, belimumab in 16, obinutuzumab in 2, voclosporin in 21, tacrolimus in 6, cyclosporin-A in 4 and azathioprine in 3 patients. Six pa…

…ndings suggest potential renal protective effects through which belimumab may prevent progression to LN.Funding: GSKOriginal presentation…

…hibitor (voclosporin or tacrolimus), or iii) mycophenolate with obinutuzumab. Following renal response, treatment should continue for at lea…