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Named medicines, compounds, vaccines, and pharmacological agents. Examples include metformin, semaglutide, antibiotics.

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466 Cancer intrinsic protein neddylation reprograms macrophage metabolism to constrain immune checkpoint blockade therapy

jitc · abstract · 2025-11-04 · 1 matching annotations

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pembrolizumab pevonedistat simvastatin RSL3 Karolinska Institutet SciLifeLab Uppsala University Swedish Cancer Society National Genomics Infrastructure in Stockholm Swedish Foundation for Strategic Research+1 more

…ed T cell expansion in pre-therapy patient samples treated with pembrolizumab. In mice bearing neddylation-deficient breast EO771 tumors, PD-…