390 Hypoxia enhances the cytotoxicity of ex vivo expanded NK cells against multiple tumor cell lines
… ERK4 signaling in NK cells expanded in the presence of IL-2 or IL-15, which can enhance NK cell cytotoxicity.1 4 Here, studies by ou…
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… ERK4 signaling in NK cells expanded in the presence of IL-2 or IL-15, which can enhance NK cell cytotoxicity.1 4 Here, studies by ou…
…nti-tumour immunity and the benefit of combination therapy with IL-15 to enhance ICI responsiveness and anti-tumour activity.Methods …
…en of nausea and vomiting was reported in patients treated with ipilimumab. 55From patient selection to TIL expansion: a comprehensive ove…
… vitro with different doses of cytokines, including IL-2, IL-7, IL-15. IL-2 stimulated human NK cells were co-cultured with human HCC…
…n of CD62L (>96%). Supplementing Synecta T1 with either soluble IL-7 and IL-15 or Synecta CK1 further enhanced expansion, with Synec…
…as selected for in vivo evaluation. In EMT6 tumor-bearing mice, IL-12/IL-15 combination therapy significantly suppressed tumor growth…
…etion and activity of different pro-inflammatory cytokines (eg, IL-15), likely associated with the lipid accumulation in MASH.7 8 How…
…KG2D), NKp46, TNF-Related Apoptosis-Inducing Ligand (TRAIL) and TIM-3. 15–4P stimulated allogeneic NK cells showed enhanced cytotoxic…
…the presence of IL-2/IL-15/IL-21. Each infusion was preceded by cyclophosphamide lymphodepletion and followed by IL-2 support. Clinical response…
…nclusions Our results demonstrate that non-viral integration of IL-15-armored CAR into the CISH locus via a simplified one-step genome editing pr…