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…iven revascularisation, serious infection or diarrhoea. For the spironolactone comparison, the outcome included all-cause death, stroke, MI, n…

…etween 0.21 to 1.45 mg/kg; all were mixed overdoses.Conclusions Colchicine overdose in children is infrequent but can be fatal. Colchicine…

…ho received low-dose colchicine compared with placebo. Low-dose colchicine was associated with a higher volume of calcified plaque, partic…

… crucial E3 ligase in this regulatory pathway. Mechanistically, colchicine suppresses DTL expression and disrupts its interaction with ABC…

…014). Tonsillectomy was ineffective. IL-1 inhibitors (anakinra, canakinumab) were beneficial in refractory cases. Cluster analysis revealed…

…ull-scale trial. This will be based on the consent rate and the colchicine discontinuation rate. Secondary objectives are testing the feas…

…curacy.Conclusion The TURPAID score did not effectively predict colchicine resistance in the JIR cohort. Its limited generalisability may …

…searched for randomised controlled trials (RCTs) data comparing colchicine versus placebo in ACS. Risk ratio (RR) and mean difference with…

…resent a case of a man in his 70s who experienced an accidental colchicine overdose (11 mg over 2 days) and was treated in our intensive c…

…t homozygous patients with severe disease requiring higher-dose colchicine and IL-1 inhibitors. Not all heterozygous patients had a mild d…

…: attack frequency increased 2.16-fold in regions with adequate colchicine access (IRR=2.16, 95% CI 1.49 to 3.12) and 3.56-fold in regions…

…e 0.5 mg/kg/day, tapered monthly to 5–10 mg/day over 12 months (prednisone group). All groups receive background standard therapy per guid…