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7drug mentions

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6MHP

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Articles mentioning 6MHP

2 articles · page 1 of 1

838 Preservation of vaccine-induced CD8+ memory T cells by melanoma-cognate CD4+ T cells in a human clinical trial

jitc · abstract · 2025-11-04 · 4 matching annotations

93.1%

6MHP cyclophosphamide 12MP Mel44 University of Virginia Fox Chase Cancer Center melanoma MD Anderson Cancer Center ClinicalTrials.gov

…on of memory CD8 + T cells in a pilot experiment and found that 6MHP vaccine preserved memory CD8+ T cells, providing initial suppor…

Phase I/II clinical trial of a melanoma vaccine targeting shared non-mutated antigens and a shared mutated BRAF neoantigen with an agonistic CD40 antibody (CDX-1140) plus TLR3 agonist (poly-ICLC)

jitc · abstract · 2026-03-03 · 3 matching annotations

95.2%

6MHP CDX-1140 mBRAF poly-ICLC CDX-1140-mediated high-risk melanoma melanoma

…ssess safety and immunogenicity. Participants received vaccine (6MHP+mBRAF+poly-ICLC) with a dose-escalation allocation of CDX-1140 …