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…Introduction Systemic sclerosis (SSc), or scleroderma, is a refractory autoimmune disorder marked by microvascular dy…

…Caveolin-1 (CAV1) are known drivers of fibroblast activation in Systemic sclerosis (SSc). We recently reported that reduction in primary cilium (PC) len…

…and reduced lung function are associated with severe fatigue in systemic sclerosis (SSc) patients. The oxygen-transport-cascade, which encompasses…

…e that TLR7 and TLR9 have opposing roles in the pathogenesis of SSc, influencing immune dysregulation and cutaneous fibrosis in div…

…ere detected in 46 patients. Although typically associated with Sjögren’s syndrome, sicca symptoms were found in only 31 anti-Ro52–positive cases.…

…ive assessment of iron deposition in the liver and the heart of hemochromatosis patients. However, quantification of iron in the hands has not …

… population. 24 patients presented with AKI: 7 with SRC, 2 with P-ANCA vasculitis, 1 with bisphosphonate related acute tubular necrosis (ATN), 9 …

…P-D and TNFSF13B were significantly higher in patients that had SSc-ILD at baseline or developed SSc-ILD during follow-up, compared to …

… morbidity and mortality in a broad population of patients with pulmonary arterial hypertension (PAH), including those with PAH associated with systemic sclerosis (S…

…l positivity occurs in up to 13% of SSc cases and up to ~31% of scleromyositis patients. Anti-PM/Scl antibodies correlate with more frequent m…

…ay limit cardiac fibrosis and may help explain heterogeneity in SSc cardiac involvement. Identifying the responsible hepatic factor…

…large SSc patient cohort.Material and Methods Data from Italian Systemic Sclerosis Progression InvestiGation (SPRING) registry were retrospectivel…