Browse diseases

…cal success in hematologic malignancies, but remains limited in solid tumors due to immune checkpoint-mediated suppression and intrinsic sig…

…rophages (TAMs), the most abundant immune stromal population in solid tumors, play a central role in shaping NK cell responses through a bro…

…ression. Importantly, CXCR3 ligands (CXCL9–11) are expressed by CRC cell lines and primary tumors, and correlate with Vδ1 T cell in…

…. A maximum tolerated dose was not reached. Two patients (9.5%; uterine sarcoma, porocarcinoma) who received one cycle of S095029 monotherapy f…

…on (PNI) is a hallmark of malignancy in solid tumors, including oral squamous cell carcinoma (OSCC), and is closely associated with poor prognosis. Emerging eviden…

…e of the main components of the tumor microenvironment (TME) of solid tumors. They have several functions, which all contribute to tumor gro…

…The correlation was 0.71 (95% CI 0.48 to 0.85) in patients with renal cell carcinoma. Repeat CD8 PET imaging on-treatment was safe.Conclusions We fo…

…r patients with previously hard-to-treat cancers. However, many solid tumors are classified as non-inflamed, meaning they are less responsiv…

…Across solid tumors, cells of the myeloid lineage—monocytes, macrophages, dendritic…

… in select cancers, but its translation to solid tumors such as ovarian cancer (OC) has been hindered by multiple factors, including tumor het…

… we used extracellular ATP (exATP), which is highly elevated in solid tumors, as a tumor-selective small molecule.Methods We generated ROSE1…

…skal-Wallis tests.Results Among the 121 evaluable patients with solid tumors enrolled in the PREDICT trial, CRP flare-responders demonstrate…