Entity family
Named diseases, disorders, syndromes, injuries, and health conditions. Examples include epilepsy, diabetes, stroke.
This disease is selected. Its supporting articles are shown below.
…These data support the advancement of a novel CAR-T therapy for metastatic gastric cancer and demonstrate the potential of TME relevant validation to acc…
…uccess against hematological cancers; however, efficacy against solid tumors has been limited, with the immunosuppressive nature of solid tu…
…AMs) promote angiogenesis, metastasis, and immunosuppression in breast cancer (BC), contributing to resistance to immune checkpoint blockade …
…ed healthcare. The limited effectiveness of CAR T cells against solid tumors, combined with toxicity from CCT, highlights the urgent need fo…
…uch transformative efficacy, however, has yet to be realized in solid tumors where CAR-T activity is hindered by poor trafficking and infilt…
…ceptor (CAR) T cell therapy has revolutionized the treatment of blood cancers, but its efficacy against solid tumors remains limited. Cytokin…
…trating Lymphocyte (TIL) therapy is an autologous treatment for solid tumors involving isolation and ex vivo expansion of polyclonal T lymph…
…c, a Phase I study is planned to test this strategy in multiple solid tumors.…
…ed. Pharmacological activity was observed in the first patient (esophageal cancer, treated at 60-120-300ug), which exhibited a non-confirmed part…
…ell therapy remains less effective against solid tumors such as neuroblastoma (NB) than hematological malignancies. Key obstacles for CAR T c…
…ncies but remains largely ineffective in immunologically ‘cold’ solid tumors. One key barrier is the downregulation of major histocompatibil…
…ntitumor activity. While TCEs are effective in the treatment of hematological malignancies, achieving clinical antitumor activity in solid tumors has been…