Browse diseases

…Objectives Systemic lupus erythematosus (SLE) remains a disease of high unmet medical need. Protean man…

… using Fridericia’s Formula (QTcF). Cutaneous manifestations of lupus were defined as CLASI-A >=8 at screening and baseline.Results S…

…et volume and red cell distribution width (RDW), in identifying lupus flares.Methods This cross-sectional study was conducted over 10…

…ll tolerated and continued to demonstrate beneficial effects on SLE disease activity, glucocorticoid dose and flares through 104 we…

…Objective SLE is a multisystem autoimmune disease characterised by chronic in…

…ve SLE and moderate-to-severe disease activity from the Spanish SLE Prospective Observational Cohort Study (SPOCS) cohort.Methods S…

…ity) in relation to anti-RNP titres.Results In 70 patients with SLE, those with high disease activity (n=45) exhibited significantl…

…m patients with SLE.Methods We established the Double humanised SLE (DhuSLE) mouse by engrafting NSG immunodeficient mice with huma…

…shment.Methods Retrospective cohort of 347 patients with active SLE receiving treatment intensification at inclusion. Comorbidities…

…d a long duration is attainable for at least some patients with SLE. The degree to which this occurs in the global patient populati…

…orresponding to a mortality rate of 11.8%.Conclusions Pediatric monogenic lupus is characterized by very early onset, significant diagnostic de…

…Objectives Randomized controlled trials (RCTs) in systemic lupus erythematosus (SLE) frequently fail in late development despite promising ear…