Browse diseases

…decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia. Blood. 2016. PMID: 26796361; PMCID: PMC4817311.Esposito CL, Au…

…ticularly in oncology. Clinically validated examples include: • Breast cancer: The Oncotype DX test analyzes 21-gene expression in hormone re…

… cells to CD1d-expressing hematological malignancies, including multiple myeloma (MM) and acute myeloid leukemia (AML). Here, we evaluated wheth…

… recently identified as a target of T-cell-directed therapy for acute myeloid leukemia (AML), based on the study reporting high BCMA abundance in AML …

…Background Challenges to developing immunotherapies for acute myeloid leukemia (AML) include the identification of suitable target antigens du…

…R-pHLA complex (PDB: 2BNQ), we substituted the peptide with the AML neoantigen and used ProteinMPNN, a deep learning-based protein …

…ected with increasing concentrations of an anti-CD33 TM against acute myeloid leukemia (HL-60) cells.Results Tracking the killing capabilities of thou…

…ls, particularly patients with hematologic malignancies such as acute myeloid leukemia (AML). Intensive chemotherapy and prolonged neutropenia place t…

…CAR) T cells emerging as a leading treatment option for various hematological cancers. Despite recent advancements, there are still challenges around…

…d CD93 chimeric antigen receptor (CAR) T cells efficiently kill acute myeloid leukemia (AML) but risk endothelial cell (EC) toxicity due to CD93 expre…

…Background Acute myeloid leukemia (AML) remains a highly aggressive hematologic malignancy with p…

…compartment in the human breast is associated with remission in triple-negative breast cancer. Science Translational Medicine 2019;11:eaax9364.Wu Y, et al. A…