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…nce has been associated with poor responses to immunotherapy in solid tumors. While much of current research focuses on their immune suppres…

…them a promising cell source for cancer immunotherapy. However, solid tumors generate a unique microenvironment characterized by hypoxia, nu…

…function, particularly in nutrient-limited environments such as solid tumors. CD28 costimulation is a critical component of T cell activatio…

…Background Macrophages pervade solid tumors where they predominantly contribute to tumor progression but al…

…e and tumor surveillance. NK cells are well-suited for treating solid tumors, where they can penetrate the tumor matrix environment, activat…

…ceptor (CAR) T-cell therapy has revolutionized the treatment of heme malignancies, multiple challenges must be overcome in order to apply this th…

… tumors. Recently, TIL therapy received regulatory approval for melanoma, underscoring the need for robust, scalable product manufacturi…

…en-expression in healthy tissues. Particularly immunotherapy in ovarian cancer (OC) has had limited success due to the absence of ‘clean’ TAAs…

…xhaustion score (right) in patients with cytogenetically normal AML…

…ult and pediatric solid tumors including neuroblastoma, glioma, melanoma and sarcoma.Acknowledgements This work was supported by researc…

…ects. These findings suggest its potential for the treatment of solid tumors in humans.…

…SC1) carcinoma and Murine Oral Carcinoma (MOC1) mouse models of HNSCC.Results We demonstrated that intratumoral augmentation of CXCL1…