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…an in SjD (p<0.0001). Sicca symptoms were more prevalent in SSc/SjD compared to SSc (p<0.0001). Interstitial lung disease (ILD) was…

…essed proteins in SjD with incident lymphoma compared with both SjD without lymphoma and healthy controls. Among the top upregulate…

…oglobulin G and A levels were inversely associated with IMD. In SjD, each unit increase in IMD reduced IgG by 6.03% (−9.84%, −2.05%…

… variants in the NADPH oxidase 2 (NOX2) complex associated with systemic lupus erythematosus (SLE), secondary antiphospholipid syndrome (sAPS), or Sjögren’s…

…ve previously been described to be deregulated in patients with SjD and other autoimmune diseases.Conclusion A plasma metabolome bi…

…icated non-immune inflammatory alterations or sialoadenosis; in SjD, GS negativity defined low-grade inflammation. Classification a…

…ssed on T cells. Despite recent development of PD-1 agonists in rheumatoid arthritis (RA), little is known about PD-1 and TIGIT coexpression in RA a…

…pus erythematosus (SLE; n=249), Sjögren’s disease (SjD; n=253), systemic sclerosis (SSc; n=247), and from 497 matched healthy controls (HC) from t…

…ntral nervous system (CNS) manifestations have been reported in SjD, though establishing a causal relationship is challenging given…

…s Current clinical serology (e.g., ANA, anti-dsDNA, anti-Sm) in systemic lupus erythematosus (SLE) does not fully capture disease heterogeneity. We recently…

…discomfort?’).Conclusions Our findings suggest heterogeneity in SjD ocular presentations that predict extraocular features of disea…

…y and structurally anchored salivary gland functional states in SjD. This framework may support clinical stratification and state-d…