Browse diseases

…dels (MC38, CT26, and E0771), including subcutaneous tumors and MC38 lung metastases.Results We successfully generated and delivered…

…er cell line and primary human innate immune cells. We used the MC38 colorectal cancer and the highly immunosuppressive B16F10 melanoma mouse models t…

… states in CT26 tumors and shifts in CD8 + T cell phenotypes in MC38 tumors. These findings support the immunostimulatory potential …

…BBL knock in mice. In vivo efficacy was assessed in a syngeneic MC38 tumor model where a 4-1BB Multabody was compared with urelumab.…

…ht junction structure and ameliorated the inflammation and ICIs colitis. Furthermore, a pharmacological screen identified the small mol…

…ffinity, leading to unwanted systemic effects, toxicity and low tumor biodistribution, which ultimately limits the clinical potential…

…AR0602 in combination with HDAC inhibitors for the treatment of solid malignancies including those resistant to current ICB therapies.…

…ated macrophages modifies responses to immunotherapy.Results In MC38 colon tumors, repeated anti-CD40 or radiotherapy created necrosis that split…