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….2% but not everyone at risk was tested. Some declined germline Lynch syndrome testing due to a lack of at-risk family members and delay getti…

… Up to one in two people will develop cancer in their lifetime. Cancer is a genomic disease. While the word ‘cancer’ represents a mult…

…Lynch syndrome, an autosomal dominant disorder caused by defective DNA mismatc…

…ng a delay in surgery due to treatment-related toxicity, namely myositis. A pathological response was observed in 98% of patients, with …

…1 gene as reported in a wide range of human diseases, including CRC.31 Inflammatory and immune cell infiltrates in mice colonic muc…

…n.Abstract O20 Figure 1T cell clones expand around the diseased Lynch syndrome bowel…

…Introduction Lynch syndrome (LS), is caused by a germline pathogenic variant in one of the …

…gure 1Forest plot of adenoma detection rate in individuals with Lynch syndrome Adenoma detection rate, expressed as proportions.Abbreviations:…

…Epithelial cell adhesion molecule (EPCAM)-associated Lynch syndrome arises from deletions at the 3′-end of EPCAM that disrupt trans…

…ective Lynch Syndrome Database (PLSD), consistently report high CRC incidence, despite regular colonoscopy. Nevertheless, mortality…

… Population-based screening for Lynch syndrome in patients with colorectal cancer: implementing the NICE diagnostic pathway. BMJ Connections Clin…

…est 1 in 350 people have Lynch syndrome (LS). The East Midlands Lynch Syndrome Expert Network (EMLSEN) was commissioned to improve LS testing …