Document resource
Antimicrobial stewardship (AMS) has advanced considerably across Europe, yet an often overlooked barrier persists: the misalignment between clinical practice and the Summary of Product Characteristics (SmPC) for many legacy antibiotics. Most off-patent agents still carry SmPCs based on decades-old data, overlooking the vast body of evidence generated since their original approval. This situation generates a paradox: healthcare professionals are encouraged to follow international guidelines and AMS principles, but regulatory information lags far behind.