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S123 Research priorities for community acquired pneumonia in the UK: a James Lind alliance priority setting partnership

thoraxjnl · 2025-11-02 · canonical JSON source

9 visible annotations · policy: published · automated confidence ≥ 75.00%

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Background Community-acquired pneumonia (CAP) remains a significant global health burden, yet key uncertainties persist regarding its optimal diagnosis, management, and long-term outcomes. The James Lind Alliance Community-Acquired Pneumonia Priority Setting Partnership (CAP PSP) aims to address these critical evidence gaps by identifying and prioritising research questions from the perspectives of patients, carers, and healthcare professionals.Methods The CAP PSP systematically gathered questions from a diverse range of stakeholders via an open survey. Respondents were sought from a wide variety of settings including patient support groups, charities, healthcare colleges, outpatient clinics, hospital inpatients and nursing home residents. Submissions were screened for scope and duplicates, see JLA website for more details on our protocol (https://jla.nihr.ac.uk/node/32856). Subsequently, questions were categorised by theme to identify future research question.Results As of June 2025, a total of 695 research responses were submitted by stakeholders, from which 912 unique questions were identified. Following the robust methodology of the JLA, 856 questions were deemed to be within the scope of the partnership, while 56 were excluded. The respondent profile reflected broad engagement, with contributions predominantly from healthcare professionals (43.7%), patients/persons with CAP (38.1%), and carers/family/friends (14.4%).Detailed thematic analysis is underway and reflects the diverse concerns of stakeholders. The highest priority themes, based on the volume of questions, include those around i) optimal follow-up, ii) preventing readmission/recurrence, iii) diagnostic methods, and iv) optimising antibiotic/adjunctive treatment strategies. Other prominent themes address comprehensive CAP management in vulnerable populations, recovery and rehabilitation, differentiation from other respiratory infections, and long-term outcomes.Next steps The identified themes will be developed into specific, answerable research questions. These questions will then be presented to stakeholders for ranking, culminating in the identification of the top 10 research priorities for CAP. The top 10 priorities will be presented at the BTS Winter Meeting 2025 and will be widely disseminated to research funders and the broader scientific community to guide future research agendas and improve patient care.Submitted on behalf of the CAP James Lind Alliance PSP Steering Group