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Please confirm that an ethics committee approval has been applied for or granted: Yes: I’m uploading the Ethics Committee Approval as a PDF file with this abstract submissionBackground and Aims Total knee arthroplasty (TKA) is a common orthopedic procedure for advanced knee disease. Several anesthetic techniques may be used to provide surgical anesthesia for TKA, with peripheral nerve blocks (PNBs) often added to improve pain control and recovery. This study assessed perioperative outcomes in patients undergoing TKA at St. Luke’s Medical Center-Global City (SLMC-GC), focusing on the impact of PNBs on hospital length of stay (LOS).Methods We retrospectively reviewed the records of 338 TKA cases, comparing postoperative pain score, time to ambulation, incidence of cardiopulmonary complications, incidence of post-operative nausea and vomiting, and LOS. Chi-squared test was used to measure categorical variables, and analysis of variance (ANOVA) for continuous variables. Statistical significance was set at p <0.05.Results Neuraxial anesthesia with PNB was the most frequently used technique (n=119, 35.2%). The addition of a PNB to either general or neuraxial anesthesia was associated with a shorter hospital LOS (4.71 ± 2.713 and 4.93 ± 2.945 days, respectively), in contrast to the longer LOS observed with general or neuraxial anesthesia without PNB (7.52 + 3.987 days). No cardiopulmonary complications were recorded in all patients. Although there were no statistically significant differences across all anesthesia techniques in terms of pain score, time to ambulation and incidence of PONV, the addition of PNB appeared to be associated with a lower incidence of PONV (1.8%).Conclusions TKA can be safely performed under various anesthesia techniques with comparable perioperative outcomes. However, adding a PNB may reduce hospital LOS and reinforce enhanced recovery after surgery (ERAS) protocols, paving the way for future implementation of ambulatory TKA – an approach that has yet to be adopted in the Philippines.