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Background The use of immunotherapy (IO) has dramatically changed the treatment landscape for non-melanoma skin cancer (NMSC), most recently with the integration of neoadjuvant IO into the treatment paradigm for resectable CSCC. However, clinicians may have concerns about incorporating IO into practice at this early stage of disease.We aimed to determine if digital, short-form, accredited medical education could improve dermatologists’, oncologist’ and surgeons’ ability to optimize integration of neoadjuvant IO into practice.Methods Between 2023-2024, US-based dermatologists, oncologists, and surgeons who treat NMSC participated in an educational curriculum consisting of 3 digital, 15-minute, accredited programs. Each program was developed to address the educational needs as they pertain to the evidence-based use of neoadjuvant IO for resectable CSCC with a goal to reinforcebaseline knowledge and competence (K/C) of learners from programs 1-3 as well as improvement in K/C within each program.Pre- and post-assessments were administered in every program to collect information regarding learners’ baseline scores and the impact of the education.Results 1,580 pre- and post-assessment responses were collected across three programs from dermatologists, oncologists, and surgeons who treat NMSC. Data collection is ongoing. Results demonstrated an improvement in K/C from pre- to post-assessment, regardless of specialty ( table 1). Results also demonstrated an improvement in baseline K/C over the duration of the 3 programs (table 1), highlighting the importance of consistent reinforcement of key clinical principles.The greatest learner improvements were seen on the questions related to identifying appropriate patients and practical implementation strategies to elevate the benefit-to-risk ratio of this treatment approach. Learners also reported an intention to improve identification of patients who would benefit from neoadjuvant IO and to work within a multidisciplinary team to enhance therapeutic decision-making.Conclusions The findings demonstrate that a focused curriculum of 3 short-format, accredited programs among clinicians is effective in improving practical K/C regarding integration of neoadjuvant IO into practice. The data also support the importance of reinforcement of key clinical principles across programs, as results demonstrated improvement in baseline K/C over the duration of the curriculum.Abstract 721 Table 1