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Large vessel occlusion (LVO) is a severe subtype of acute ischaemic stroke, for which endovascular therapy significantly improves clinical outcomes. Expediting time to reperfusion is critical; however, conventional in-hospital workflows based on CT or MRI are frequently hindered by treatment delays. Direct Transfer to the Angiography Suite (DTAS) is an emerging care strategy in which patients with suspected or confirmed LVO bypass the emergency department and standard imaging. Using flat-panel CT or sliding-gantry CT combined with digital subtraction angiography, the DTAS workflow facilitates rapid diagnosis and prompt reperfusion therapy, thereby significantly reducing door-to-reperfusion time. Drawing on evidence from international and domestic studies, the Chinese Stroke Association convened an expert panel to develop this guideline, which systematically delineates the DTAS strategy, infrastructure requirements, diagnostic and therapeutic workflows and quality control indicators.