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Application for ESRA Abstract Prizes : I apply as an Anesthesiologist (Aged 35 years old or less)Background and Aims Laparoscopic cholecystectomy is associated with significant pain after surgery and is one of the most common causes of readmission after ambulatory laparoscopic cholecystectomy. The external oblique intercostal (EOI) block is a more recently described regional anesthesia approach to anesthetize the upper abdomen which is easy to perform and may provide effective analgesia for laparoscopic cholecystectomy.Methods We report of three cases aim to describe the use of the EOI block in providing analgesia following laparoscopic cholecystectomy. After induction of general anesthesia, the EOI block was performed using an ultrasound-guided in-plane approach. Local anesthetic was injected between the fascial plane of the external oblique muscle and the external intercostal muscle at the level of the intercostal space between the 6th and 7th rib.Results Three female patients, aged 62 to 71 years, underwent laparoscopic cholecystectomy under general anesthesia with an EOI block. None of the patients required opioids for intraoperative analgesia beyond induction. Postoperatively, all three patients reported only mild-to-moderate pain localized to the umbilical port site. Postoperative opioid consumption was minimal. No adverse effects or block-related complications were observed.Abstract P155 Figure 1A typical ultrasound image obtained while administering the external oblique intercostal (EOI) block. The external oblique muscle, intercostal muscles, 6th rib, 7th rib, and pleura is labelled. The external oblique muscle border is outlined in cyanConclusions In conclusion, the EOI block is effective for analgesia in laparoscopic cholecystectomy and should be considered in routine peri-operative strategies. Further research may explore its role in other laparoscopic upper abdominal surgeries and compare its efficacy with blocks offering sympathetic visceral coverage, such as the ESP or paravertebral blocks. Cadaveric studies may also help clarify its anatomical basis for such coverage.