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Objective Patients with COVID-19 are admitted to ICU as a result of hypoxia caused due to pneumonia. Many of these patients are ventilated using Mechanical Ventilator in order to maintain the desired oxygen Saturation. Proprioceptive neuromuscular facilitation has shown beneficial effects among patients on ventilator. Objective of this study is to compare the efficacy of Proprioceptive Neuromuscular Facilitation on respiratory rate, saturation of peripheral oxygen and heart rate.Methodology 13 patients from ICU of Al Ain hospital were taken for the study who fulfilled the eligibility criteria and was systematically divided into Group A (PNF with Conventional Physiotherapy) and Group B (Conventional Physiotherapy). Patients were given the intervention according to their allocated group for 3 days and effects of these techniques on RR, SpO2 and HR parameters were observed. Data was taken at baseline and after 3 days of intervention.Result Data was analyzed using Paired and Unpaired t-test. Statistically significant improvements were observed in both groups but were more pronounced in Experimental Group in terms of Respiratory Rate (t value 2.626) and Oxygen Saturation (t value 1.33) compared to Control Group. However, significant mean difference was noted in Experimental Group in terms of Respiratory Rate (8.67), Heart Rate (10.5), Oxygen Saturation (2) and Fraction of Inspired Oxygen (10.84) .Whereas in Control Group slight improvement was noted in terms of Respiratory Rate (0.43), Heart Rate (9.71), Oxygen Saturation (2.57) and Fraction of Inspired Oxygen (13.29).Conclusion Study concluded that significant improvement was noticed in terms of Respiratory Rate and Oxygen Saturation in Experimental Group when compared to Control Group. However, improvement was noted in other parameters like Heart Rate and Fraction of Inspired Oxygen which was not significant statistically.