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Introduction CT-guided lung biopsy (CTGB) is a minimally invasive procedure that enables histological diagnosis and aids with personalized patient care. However, this procedure has its own significant risks and complications with pneumothorax being the commonest complication. We present the important characteristics of patients that developed pneumothorax in our tertiary care centre caused as a result of CTGB.Methods A retrospective analysis of all requests for CTGB lung from 1/01/2023 till 31/12/2023 was conducted. This service is provided 5 days a week in our busy tertiary care hospital. Total number of patients undergoing procedure and developing pneumothorax were identified and common characteristics were recorded in patients that developed pneumothorax in detail. The management of the iatrogenic pneumothorax was also studied.Results Of the 173 patients that underwent CTGB, 53 (30.63%) developed iatrogenic pneumothorax. Majority of these patients (n=34, 64.15%) were managed conservatively. However, 19 patients had interventions (35.84%). 44 patients developed small pneumothorax (83.01%), 5 had large (9.43%) with 4 moderate pneumothoraxes (7.54%) as per radiological reports and features.23 patients who developed pneumothorax had background emphysema (43.39%) whilst 30 did not have emphysema (56.60%). The mean age of patients developing pneumothorax was 71 years. 33(62.26%) of them were male patients and 20 were females (37.73%).The most common position for the nodules in patients developing pneumothorax was RUL (n=18) followed by RLL (n=14), LLL (N=10), LUL (N=9) and RML (N=2). Majority of lesions were >3 cm (N=39), followed by lesions 1–2 cm (N=12) and there was 1 lesion that was 2–3 cm. In 5 patients the lesions were crossing the fissure whilst it was not crossing in 43 patients. 40 (75.47%) patients with iatrogenic pneumothorax had their lung functions recorded before the CTGB. FEV1 was >80% in 24 patients and between 50–80% in 16 patients.Abstract P82 Figure 1Conclusion Iatrogenic pneumothorax is a well recognised complication of CTGB which can lead to invasive interventions, the rates of invasive interventions being variable in different centres and hospital admissions. We provided an overview of the common important risk factors and characteristics of patients that developed iatrogenic pneumothorax from our cohort.