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Introduction Recanalization rates are typically lower in ICA occlusions, with first-pass mTICI 2b-3 rates ranging from 30% to 50% due thrombus length and anatomical complexity. The NeVa stent retriever has demonstrated high recanalization effectiveness with a favorable safety profile in mechanical thrombectomy of LVOs.Aim of Study NeVa ONE is a multicenter, international, prospective registry designed to assess outcomes in a real-world patient cohort.This interim analysis descriptively compares different lesion locations and corresponding recanalization outcomes.Method This analysis includes 350 patients treated using NeVa as a first-line approach.Outcomes are assessed across occlusions in the ICA, MCA (M1, M2), and BA.Endpoints include successful (TICI2b-3) and complete (TICI 2c-3) recanalization achieved at first pass (mFPE/FPE) and at procedure end.Secondary endpoints include device/procedure-related adverse events.Results Occlusion sites were: ICA (28.0%), M1 (57.1%), M2 (10.9%) and BA (4%).Baseline characteristics were comparable across lesion locations with slight deviations for the smaller-sized basilar artery group:Age 67–72 years, NIHSS 13–16, ASPECTS 8–10.Common comorbidities included hypertension (68–75%), dyslipidemia (43–50%), diabetes (20–33%), and atrial fibrillation (25–43%).mFPE rates were 66.7% (ICA), 77% (MCA M1), 81.6% (MCA M2), and 71.4% (BA).Corresponding FPE rates were 53.5%, 65%, 52.6%, and 50%.Conclusion The NeVa ONE Registry reflects real-world outcomes for LVO AIS patients treated with NeVa.Recanalization rates for ICA occlusions were comparable to other lesion locations, highlighting NeVa’s consistent performance across complex territories.Conflict of Interest No