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Background With expanding use of immune checkpoint inhibitors, the incidence of immune-related adverse events (irAE) is on the rise. 1 The Alliance for Support and Prevention of irAEs (ASPIRE) conducted a needs assessment survey to evaluate educational preferences and barriers to effective irAE management across specialties.Methods An anonymous survey was distributed via social media and at the in-person ASPIRE Consortium and ASPIRE Community of Practice meetings between February and June 2025. Descriptive statistics summarized response frequencies. Chi-square tests were used for categorical variables and Kruskal-Wallis for ordinal variables.Results Of 161 respondents, 66% were physicians, and the remainder non-physician clinicians (NPCs) [advanced practice providers (APPs) (21%), pharmacists (7%), and nurses (6%)] – the majority practiced at academic centers (73%) and urban settings (70%). Primary specialties included hematology/oncology (65%), internal medicine (8%), emergency medicine (4%) and rheumatology (4%). Formal irAE education occurred less than annually or quarterly for most; however, respondents from NCI centers and urban areas participated more frequently than clinicians from other practice settings (p<0.01 and p=0.04, respectively).Amongst educational formats, physicians preferred standardized guidelines more than NPCs, with latter preferring educational talks (table 1). Regarding educational platforms, NPCs more frequently preferred webinars, symposiums, and online modules, and less frequently social media compared to physicians (table 1). Rural/suburban clinicians preferred institutional training programs more than urban counterparts (p=0.04).Median overall confidence in recognizing and managing irAEs was 4/5 and 3/5, respectively amongst all respondents, with higher scores among academic participants compared to non-academic practices (p=0.02). Common barriers for effective irAE management included lack of institutional protocols, insufficient training among staff, and care coordination (figure 1). Overall, 50% of respondents reported institutional support for irAE management with only a minority with access to dedicated irAE teams (32%) or remote symptom monitoring (10%). Academic centers and urban practices were more likely to have institutional support for irAE education/management compared to participants from community and rural/suburban areas (p < 0.01 and p = 0.03, respectively).Conclusions Consistent with prior literature 1 2 our findings highlight persistent gaps in irAE education, institutional support, and care coordination across practice types. Preferences for irAE educational formats and platforms vary by role and setting, underscoring the need to develop tailored educational resources. Our findings additionally support the development of institutional frameworks to strengthen irAE management across diverse practice settings, especially suburban and rural settings.References Brazel D, Kazakova V, Fay M, Bollin K, Mittal K, Reynolds KL, Tsang M. Connecting the dots: practical strategies for academic and community oncology synergy to advance multidisciplinary management in immunotherapy toxicity care. Am Soc Clin Oncol Educ Book. 2025;45(3):e473080.Wesevich A, He G, Tomczyk G, Reid P. Role-specific curricular needs for identification and management of immune-related adverse events. J Cancer Educ. 2023 Oct;38(5):1486-1492.Ethics Approval The study (STUDY00002377) was approved by the institutional review board of UMass Chan Medical School. The participants gave informed consent prior to taking the survey.Abstract 1062 Table 1Preferred formats and platforms for immune-related adverse events education by clinical roleAPPs, advance practice providersAbstract 1062 Figure 1Barriers to effective management of immune-related adverse events. IrAE, immune-related adverse events