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Background and Aims The optimal locoregional analgesic strategy for total knee arthroplasty (TKA) remains debated. Proximal nerve blocks, such as femoral nerve block (FNB), provide effective in analgesia up to 24 h postoperatively. However, this proximal approach is often associated with quadriceps weakness, potentially hindering early mobilization. The femoral triangle block (FTB), a more distal sensory nerve block, represents a promising alternative, potentially balancing effective analgesia with preservation of quadriceps strength.Methods We conducted a retrospective study to compare analgesic quality and functional recovery in patients undergoing TKA under general anesthesia and receiving either single-shot FNB or single-shot FTB between August 2023 and August 2024. Ethical approval was granted (S70459). Pain was assessed using the Numeric Rating Scale (NRS) over the first 24 hours postoperatively. Secondary outcomes included time to ambulation, time to full weight-bearing, opioid consumption, and early quadriceps function assessed by straight leg raise and knee extension tests.Results We identified 129 patients, with 55 receiving FNB and 74 FTB. Our results showed comparable analgesia between the two groups, although a transient increase in pain was observed in the FNB group at one evaluation point ( figure 1). Opioid consumption and time to ambulation were similar between groups (table 1). However, patient receiving FTB achieved full weight-bearing sooner (figure 2).Abstract EP115 Figure 1Abstract EP115 Figure 2Abstract EP115 Table 1Comparison of functional and analgesic outcomes between FNB and FTB for TKAConclusions In conclusion, in patients undergoing TKA, single shot FTB provides analgesia comparable to FNB and was associated with earlier achievement of full weight-bearing recovery. These findings suggest that FTB may be a beneficial analgesic strategy in this clinical context.