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Background and Aims The management of chronic hip pain requires accurate diagnosis and a multimodal approach. This study aimed to evaluate the effect of posterior quadratus lumborum block (QLB) on pain and quality of life in patients with chronic hip pain.Methods After Ethical committee´s approval (PI 21-PI104) and registration (Trial registration number: NCT04438265) we started this prospective cohort study. A sample size of n=200 was calculated to ensure that a two-sided test with α = 0.05 would have 90% power to detect a 5% difference in the proportion of patients receiving pain treatment, with 95% confidence. All patients were suffering from chronic hip pain. The intervention group received posterior quadratus lumborum block as an analgesic technique and control group did not. Pain (NRS) and quality of life (WOMAC questionnaire) were assessed at baseline, three weeks, three and six months in both groups. The block was considered effective if, three months after the block, in the QLB group, pain decreased by a mean NRS ≥ 3 during daily activity or a WOMAC global score of 24–26 points.Results There were no differences in demographic data( table 1),The QLB group showed significant improvements in pain and quality of life at three months compared to baseline (NRS mean 7/4; and WOMAC mean 59/35) (p value = 0.001), while the control group scores remained unchanged (NRS 7/8; and WOMAC (61/61) (figure 1). At three months, 50 patients in the QLB group showed an improvement more than 50% in NRS and WOMAC scores (ten of those patients had an improvement for more than one year). We observed that patients with avascular necrosis showed a minor improvement. Only two adverse events were registered (an unexpected spread and an allergic reaction)Abstract EP031 Figure 1Graphic resultsAbstract EP031 Table 1Conclusions Our results suggest that posterior QLB could represent a minimally invasive option in chronic hip pain.