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Objectives The most common cause of death in systemic lupus erythematosus (SEL) are cardiovascular (CV) diseases. The aim of this study is to show the CV risk for our patients, the mutual correlation of scores as well as the association of the scores with clinical characteristics.Methods The 50 SEL patients were included in the study. The demographics, cardiovascular risk factors and laboratory parameters were collected. The QRISK3, SCORE2 and FRS were calculated and compared to each other. All collected variables were compared with QRISK3.Results The total number of female subjects was 48 (96%), the average age of the subjects was 47.48±12.93, and the duration of the disease was 10.46±7.72 years. In total, there were 3 (6%) smokers and 2 (4%) diabetics. Four (8%) patients had lupus nephritis, while 23 (46%) had hypertension. There were 38 (76%) on active treatment with corticosteroids, and 40 (80%) on hydroxychloroquine treatment. Twenty-six (52%) patients had positive anti-dsDNA antibodies, and 17 (34%) anti-Ro. Total cholesterol values are 6.0±0.95 and HDL 1.39±0.36. The average systolic blood pressure was 122.3±9.7, and diastolic blood pressure 76.9±8.97. The average of QRISK3 was 12.05±10.8, SCORE2 2.72±2.31, and FRS 2.35±2.76. Patients with high risk were 21 (42%) in QRISK3, 9 (18%) in SCORE2, and 1 (2%) in FRS. The correlation between QRISK3 and the two previously mentioned scores was statistically significant (r = 0.907, p<0.001, and r = 0.911, p<0.001). There were statisticaly significant correlation between QRISK3 and: smoking (p=0.02), hypertension (HTA) (p <0.001), the presence of anti-Ro antibodies (p=0.04) and the use of hydroxychloroquine (p=0.01). It is also significantly correlated with age (p<0.001, r=0.076) and disease duration (p=0.03, r=0.298). Relationships with other variables were not statistically significant.Abstract PO:03:073 Figure 1Display of risk stratification of patients with different scoresConclusions QRISK3 showed more patients with high risk of CV events than SCORE2 and FRS. Also, we have showed statistically significant correlation between QRISK3 and risk factors such as smoking and HTA, as well as: age, disease duration, anti-Ro antibodies and hydroxychloroquine. We emphasize the importance of using this QRISK3 in order to recognize patients with higher CV risk so that we are able to enforce adequate management.