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Introduction The iNstroke aspiration catheter (iVascular) is a single-lumen, 0.071’’ device with proximal-to-distal-decreasing stiffness, specifically designed to remove thrombi from neurovascular blood vessels.Aim of Study To evaluate the efficacy and safety of the iNstroke aspiration device in mechanical thrombectomy for patients presenting with acute ischemic stroke (AIS) due to large vessel occlusion within 24 hours of symptom onset.Method ASPIC-01 is a prospective, single-center clinical trial. Primary efficacy endpoints included successful recanalization (mTICI≥2b) and good functional outcome (modified Rankin Scale (mRS) 0–2 at 90 days. Safety endpoints included serious adverse events (SAEs) at 24 hours and all-cause mortality at 90 days. The intention-to-treat population included all eligible patients while the device analysis set included those treated exclusively with iNstroke.Results Interim analysis (n=81) showed successful recanalization in 82.7% patients and good clinical outcomes in 65.7% (mRS 0–2 at 90 days). Final data from the full cohort (n=113; mean age: 70.7±12.5 years; 47.8% female) are currently under analysis and will be presented for the first time at ESMINT 2025.Conclusion Preliminary results suggest that the iNstroke catheter is a safe and effective option for mechanical thrombectomy in AIS. The final analysis with 113 patients is expected to provide stronger evidence supporting the use of iNstroke and aspiration as a viable frontline strategy for large vessel occlusion stroke.Conflict of Interest No