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Introduction Patients with multiple comorbidities are at increased risk of complications and poor outcomes after endovascular thrombectomy (EVT).Aim of Study This study aims to analyze procedural and clinical outcomes following EVT on minor stroke patients with varying levels of comorbidity burden.Method We conducted an observational study of all pre-stroke independent patients treated with EVT for minor stroke (NIHSS<6) from 2015 to 2021 in Sweden. Comorbidity burden was categorized using the Charlson Comorbidity Index (CCI) into no (CCI 0), low (CCI 1–2), and severe (CCI>2) comorbidity burden. Outcome measures included successful recanalization (mTICI 2b-3), delta-NIHSS and modified Rankin Scale (mRS) 0–2 at 90 days.Abstract A72 Figure 1Results Among 370 patients, 44% had CCI 0, 33% had CCI 1–2 and 23% had CCI>2. In the CCI 0-group, 75% had a mRS of 0–2 after 90 days compared to 60% in the CCI 1–2-group and 40% in the CCI>2-group. The CCI>2-group had lower OR of mRS 0–2 compared to the CCI 0 group (OR 0.28, 95% CI 0.15–0.51). Successful recanalization was associated with good functional outcome in all groups expect for the CCI>2-group (CCI 0: OR 2.92, 95% CI 1.03–1.30; CCI 1–2: OR 4.08, 95% CI 1.31–12.70; CCI ≥3: OR 0.80, 95% CI 0.26–2.50).Conclusion This study demonstrates that increasing comorbidity burden is associated with worse outcome in minor stroke patients treated by EVT, and that patients with severe comorbidity do not benefit from succesful recanalization in terms of functional outcomes at 90 days.Conflict of Interest No