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Embolization of distal intracranial pathology including small distal aneurysms, mycotic aneurysms, pseudoaneurysms, arteriovenous malformations (AVMs), and dural arteriovenous fistulas (AVFs) may require small, navigable microcatheter systems that are compatible with liquid embolic materials as well as coils. More navigable microcatheters with internal diameters (IDs) of 0.013’ may improve the ability to access distal vasculature but are not compatible with standard 0.010’ or 0.014’ coil systems. Here, we describe the role of the Kaneka i-ED COIL system (Kaneka Medical America, NY, USA) for embolization of distal intracranial pathology. The Kaneka i-ED coils have an 0.010’ primary diameter but are indicated for use with 0.013’ microcatheter systems, such as the Apollo, Marathon, and Headway Duo 167cm microcatheters, ideal for distal intracranial embolization. We describe 6 cases of distal intracranial pathology treated with either a Marathon, Apollo, or Headway Duo 167cm microcatheter and the Kaneka i-ED COIL system. We report a series of 6 patients (mean age 42.0 years, range 5 days - 71 years) who underwent distal intracranial embolization using 0.013″ microcatheter systems in conjunction with the Kaneka i-ED COIL system. Pathologies treated included arteriovenous malformations (n=2), mycotic aneurysms (n=2), aneurysmal subarachnoid hemorrhage (n=1), intracranial hemorrhage/subarachnoid hemorrhage (n=1), and vein of Galen malformation (n=1). Lesions were located in distal vascular territories, including distal branches of the anterior cerebral artery, lenticulostriates, posterior choroidal artery branches, superior cerebellar artery, and M3-M4 segments. All procedures were successfully performed using highly navigable microcatheters (Marathon, Apollo, or Headway Duo 167cm). Adjunct liquid embolic agents were used in select cases, with n-butyl cyanoacrylate (n-BCA) utilized in 2 of 6 cases, primarily for high-flow arteriovenous lesions (AVM, vein of Galen malformation). The remaining 4 cases were treated with coil embolization alone. There were no reported procedural complications. Angiographic outcomes demonstrated effective embolization, with complete or satisfactory occlusion achieved in all treated lesions. In conclusion, the Kaneka i-ED 0.010’ coils are ideal for coil embolization of distal intracranial pathology through smaller, more navigable microcatheter systems with an 0.013’ ID. Here, we describe their role for distal intracranial coil embolization and demonstrate their utility in a small case series.Disclosures A. Kappel: None. K. Khatibi: None.