Document resource
Background and Importance Parenteral nutrition is an essential tool in patients who are unable to receive oral or enteral nutrition.However, its prolonged use is associated with hepatobiliary complications.Recent studies suggest that the lipid composition could play a key role in preventing these disorders. Understanding how factors such as lipid type, body mass index, and duration of treatment influence liver function is essential for optimising therapy and reducing complications.Aim and Objectives The primary goal is to determine whether changing the lipid composition of parenteral nutrition reduces hepatobiliary disorders.Secondary goal is to study whether variables can influence liver damage caused by nutrition.Material and Methods Retrospective observational study in a tertiary hospital including adults receiving nutritional support in 2021–2022 and 2024. Patients from 2021–22 received CL1 (refined olive + soybean oils); in 2024, CL2 added MCTs and omega-3 fish oils.Data collected included sex, weight, height, BMI, energy requirements, stress factors, duration of support, and caloric/lipid intake. Hepatobiliary complications were assessed.Statistical analysis: Stata 17; multivariate logistic regression identified factors associated with liver injury.Results 151 nutritional cases were obtained, (52.98% women) with a median age of 70 years (range 55-77).27.81% of patients received CL1.The anthropometric data of the patients were: median weight of 66.4 kg (range 57-78.5), median height of 167 cm (range 160-173.5), and BMI of 23.7 kg/m2 (range 21.2-27.2).The mean caloric intake was 24.29 ± 6.22 kcal per kilogram of weight, and the mean lipid intake was 0.91 ± 0.22 grams of lipids per kilogram of weight.31.20% of patients with CL1 had hepatic complications, compared with 31.7% in the case of CL2.Logistic regression analysis showed that the new lipid formulation was not associated with significant changes (OR = 0.99; 95% CI: 0.46-2.14).It could not be demonstrated that duration of nutrition (OR = 1.03; 95% CI: 0.98-1.08) was a risk factor.Total caloric intake (OR = 1.09; 95% CI: 1.02-1.16) and lipid intake (OR = 10.78; 95% CI: 1.92-60.59) were shown to be risk factors.Conclusion and Relevance In our population, no change in hepatobiliary complications was observed with lipid composition changes. The sample size may have been insufficient.Other variables like caloric and lipid intake seem to influence hepatobiliary complications.Conflict of Interest No conflict of interest