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Ambient temperatures and air pollution are considered as the most important environmental health risk factors causing more than half a million premature deaths every year in Europe alone. However, there is still an insufficient understanding of other short-term health impacts such as occupational health. Horizon Europe MSCA project OCCU-GUARD and OP JAC - MSCAfellow7_MUNI project ANThROPOCENE will analyse occupational accident risks associated with the joint exposure to ambient temperatures and air pollution in Europe, describe its modification by key socioeconomic factors, project the future temperature-related occupational accidents burden under different climate change scenarios, and develop a new generation of Pan-European multi-hazard occupational health early warning system accounting for real risks and impacts on the vulnerable workforce. Towards these aims, we already generated an enormous database with daily counts of occupational accidents disaggregated by sociodemographic vulnerable groups from nine European countries – namely, Austria, Belgium, Italy, Spain, Switzerland, Sweden, Czechia, Estonia, and Ireland. We are currently seeking to further expand the database. Detailed characterization of epidemiological models between temperatures and air pollution and occupational health records is ongoing. Data collection for further analysis of the effect of macroeconomic cycles and socioeconomic factors on these relationships started. Further, the projects will project future occupational accidents burden and will use above mentioned models to transform temperature and air quality forecasts into occupation health predictions representing the first Pan-European multi-hazard occupational health early warning system. ANThROPOCENE and OCCU-GUARD projects will largely contribute to the EU Strategic Framework on Health and Safety at Work because it will allow the activation of fit-for-purpose alerts and emergency plans directly targeting vulnerable groups, which is relevant information to key end-users such as industries concerned with workforce well-being, outdoor workers, trade unions, healthcare institutions, insurance companies and others.