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Application for ESRA Abstract Prizes: I apply as an Anesthesiologist (Aged 35 years old or less)Background and Aims Modern medicine has led to the development of more minimally invasive procedures, which require anesthetic techniques that parallel these surgical advancements. Studies have shown that peripheral nerve block is an essential component of multimodal analgesia that is well-tolerated and may provide superior analgesia compared to other modalities.Methods This case report details a 47-year-old female patient with no known comorbidities who complained of chronic low back pain associated with bilateral numbness in the gluteal area. The patient underwent endoscopic lumbar discectomy at L5-S1 level under a single-level left-sided ultrasound-guided erector spinae plane block (ESP) and right sided thoracolumbar interfascial plane (TLIP) block with Dexmedetomidine as IV infusion for moderate sedation. 0.5% Bupivacaine isobaric 20 ml on each side per level was used respectively.Results The perioperative course was unremarkable, with lower pain scores, minimized opioid use, and higher patient satisfaction. This case study highlights the potential of ESP block and TLIP block combined with sedation as an effective anesthetic technique in future minimally invasive spine surgeries.Conclusions As applied to this case, the safety and efficacy profile of the ESP and TLIP block supports its consideration as a feasible option in pain management. Further clinical studies may be essential in establishing evidence-based and standardized protocols for its use as perioperative analgesia in spine surgeries.