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As Archives of Disease in Childhood (ADC) celebrates 100 years and looks back at some of the remarkable changes that have taken place in paediatrics over this time, it presents an obvious opportunity to also look to the future. How might paediatrics in the UK look in another century? How will academic and clinical research findings be published? Reflecting on commentaries and opinions from esteemed colleagues in this centenary edition, it is clear that advances which were once considered ground-breaking and novel have been widely adopted into routine clinical practice.