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A recent study by Erkert et al identified a new role for Alzheimer’s disease (AD)-associated presenilins as key molecules involved in maintaining intestinal epithelial function, barrier integrity and immune homeostasis, linking AD and inflammatory bowel disease (IBD) at the molecular level.1 2 Meanwhile, Zhang et al, from an epidemiological perspective, reported that individuals with IBD have a higher risk of developing dementia, particularly AD.3 The ‘gut-brain axis’, which links the intestine and the central nervous system (CNS), has received significant attention in recent years.