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We read with great interest the recent EPOC trial by Miyakawa et al, published in Gut, investigating the efficacy of prophylactic clip closure following colorectal endoscopic submucosal dissection (ESD). The authors deserve recognition and appreciation for conducting a well-designed, multicentre randomised controlled trial (RCT) that focused on clinically meaningful endpoints and included a robust per-protocol analysis. Notably, this study addresses a significant gap in the literature by setting delayed bleeding as the primary outcome, which distinguishes it from prior trials where bleeding was only a secondary endpoint. The findings provide valuable evidence supporting the role of prophylactic clip closure in enhancing post-ESD outcomes.