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Background and Importance Pre-Exposure Prophylaxis (PrEP) is a key HIV prevention strategy. The recent introduction of long-acting injectable cabotegravir (LA-PrEP) has expanded the available options beyond oral therapies. This innovation requires a deep understanding of user preferences to guide personalised therapeutic choices, improve adherence, and optimise the service. In this context, monitoring satisfaction and tolerability and ensuring the appropriate use of different formulations is a crucial activityAim and Objectives To assess the degree of satisfaction, tolerability, and user preferences for different PrEP strategies (daily oral, on-demand oral, long-acting injectable) in order to identify user profiles and enhance the quality of careMaterial and Methods An anonymous survey was administered via REDCap platform to all individuals receiving PrEP at our University Hospital. The questionnaire collected data on current and previous PrEP regimens. Satisfaction with effectiveness, ease of use, impact on daily life, and tolerability were measured using a 5-point Likert scale. Reasons for switching therapy and future preferences were also investigated. Data were analysed using descriptive statistics and correlation tests.Results Analysis of 282 responses (45% on daily oral PrEP, 12% on-demand, 44% on LA-PrEP) reveals distinct user profiles. LA-PrEP users are significantly older than on-demand users (36-55 age groups vs 26-35 for on-demand; p<0.001) and are more likely to have previously switched regimens. Overall satisfaction is extremely high (97%). However, on-demand users report the lowest satisfaction with convenience and the greatest impact on sexual spontaneity. Consequently, they show the strongest future preference for LA-PrEP (85.7%). For LA-PrEP users, injection experience is positive (>85%) and provides greater peace of mind (>90%). While injection site pain is common, discomfort is considered acceptable by almost 90%.Conclusion and Relevance The introduction of LA-PrEP effectively meets the needs of an older, experienced user seeking convenience. The younger, on-demand user represents the primary candidate for a future switch, driven by a desire for greater spontaneity. This tailored approach is fundamental for service sustainability, ensuring that the more resource-intensive LA regimen is directed towards the users who will benefit most. Synergy between the infectious disease specialist’s and the hospital pharmacist’s is therefore essential for optimising clinical outcomes while ensuring the long-term efficiency and viability of the PrEP program.Conflict of Interest No conflict of interest