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Background and Aims Wrong-site peripheral nerve blocks (WSBs) are rare but serious ‘never events’ in regional anesthesia. In February 2024, three near-miss WSB incidents at St. Luke’s Medical Center – Global City revealed critical gaps in site verification, interprofessional communication, and documentation. This study aimed to evaluate a structured safety intervention to reduce WSB risk and improve site verification practices.Methods Following formal root cause analysis, a multidisciplinary team employed the Plan-Do-Study-Act (PDSA) framework to implement a locally adapted ‘Stop Before You Block’ (SBYB) protocol. Key components included mandatory dual-provider verification, standardized skin marking, integration with the WHO Surgical Safety Checklist, electronic documentation via the hospital EMR, and targeted staff education supported by visual aids. A six-month pilot was conducted in the main operating rooms (March–August 2024).Results Protocol adherence increased from 62% at baseline to 95% post-implementation. No WSBs occurred. Five near-miss events were identified and intercepted through improved verification. The average verification time was 90 seconds, with no impact on procedural flow. Compliance was highest for dual-provider checks (98%) and lowest for EMR documentation (89%). Staff surveys showed increased confidence in procedural safety. Sustained adherence above 90% was maintained throughout the six-month pilot, supporting plans to expand the protocol beyond the main operating rooms.Conclusions The implementation of the adapted SBYB protocol enhanced procedural safety in regional anesthesia by ensuring consistent site verification and reinforcing team-based accountability. Its demonstrated feasibility and sustainability support broader adoption in perioperative settings beyond the operating room.