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Rates of fluconazole-resistant Candida albicans and non-C. albicans yeasts are increasing in the UK. In Leeds, between 2018–2019 and 2020–2021, the percentage of non-C. albicans yeasts rose from 6.0% to 12.6% and fluconazole dose-dependent/resistant isolates increased from 3.5% to 9.6%.1 Prolonged courses of self-purchased antifungals,2 and presumptive diagnoses with inappropriate empirical treatment,1 have been associated with fluconazole resistance. Clinical symptoms and signs of vulvovaginal candidiasis (VVC) are non-specific, and empirical antifungal prescribing results in over 50% of antifungals being ineffective or unnecessary.3