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Introduction Nonacute subdural hematomas (nSDH) are common yet serious extra-axial hemorrhages that result in significant morbidity and mortality. Middle meningeal artery (MMA) embolization (MMAE) is a recent endovascular treatment that involves occlusion of the MMA, inducing hemostasis in and around the hematoma. While many aspects of MMAE have been explored, there is currently limited data on the optimal extent of embolization.Objective To determine whether single or multiple pedicle embolization of the MMA is superior in inducing hemostasis in nSDH.Methods We compared single versus multi pedicle embolization by a retrospective multicenter analysis of nSDH patients who underwent MMAE between 2019 and 2024 at participating centers in the MESH (MMA Embolization for Subdural Hematoma) Registry. 679 patients who received a liquid embolic agent with branch-level embolization data were included.Results While multi-pedicle embolization hastened nSDH thickness reduction at 1-month follow-up, by 3 months the groups had converged. Multivariate linear regression did show superior 90-day mRS in the multi-pedicle group, suggesting a potential long-term benefit to more extensive MMAE.Conclusion Future, multi-center randomized prospective trials are warranted to address confounding variables that limit this observational study.Disclosures G. Thrash: None. B. DeMessie: None. E. Wang: None.